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However, the primary clinical concern isn’t the primary tumor, however the prospect of that tumor to keep its cells of origin and pass on through the entire body . A crucial part of metastatic progression of epithelial cancers occurs when epithelial cells revert to a much less differentiated state – an activity called epithelial-mesenchymal changeover or EMT. Ophthalmologist Min Chang, M.D., research the healing up process in the cornea, the most highly regulated epithelium in your body perhaps. From collaborative research with David Bader, Ph.D., who found out BVES and demonstrated its importance in center development, Chang discovered that BVES was extremely expressed and regulated in corneal cells.