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An orally bioavailable prostacyclin receptor agonist could improve the standard of care for patients with PAH, a life-threatening disorder, said William R. Shanahan, M.D., Arena’s Senior Vice President and Chief Medical Officer. APD811 is usually a non-prostanoid substance; in preclinical studies, the oral uptake, fifty % life and efficacy features suggest that it could offer improved administration over current prostacyclin receptor therapies. This randomized, double-blind and placebo-controlled Stage 1 trial is planned to sign up up to 72 healthful adult volunteers and will evaluate the safety, tolerability and pharmacokinetics of single-ascending doses of APD811. While our primary focus is on attaining FDA approval of lorcaserin for weight reduction, we see worth in advancing our promising earlier-stage compounds that could also address underserved medical needs, stated Jack Lief, Arena’s President and CEO.