Cancer radiotherapy can increase risk of coronary disease later in life For an up to now unknown reason, cancer radiotherapy can raise the risk of cardiovascular disease later in life, a nagging problem that is growing as more and more people survive their cancer medical diagnosis ?loop diuretics . New research from Karolinska Institutet right now suggests that sustained irritation induced by post-radiotherapy adjustments in the gene expression in the arteries could be the cause. Epidemiological studies have shown that a course of radiotherapy increases the risk of coronary disease in the same section of the body; for instance, myocardial infarction after left-side breast cancer treatment, or stroke following the treatment of mind and neck or brain tumours.

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McMahon. McMahon’s group demonstrated that USP22 is required for activation of target gene transcription by the MYC oncoprotein and that USP22 depletion compromises MYC functions, including transformation of mammalian cells, and prospects to cell routine arrest. Taken together, these results significantly progress the knowledge of mechanisms that permit fine-tuning of transcriptional regulation by revealing that the hSAGA histone acetyltransferase complex can be with the capacity of histone deubiquitylation. The results provide critical new information about the need for the timing and sequence of chromatin adjustments in the control of gene expression in normal cells and reveal the biochemical function of cancer tumor stem cell marker and hSAGA subunit USP22, determining it as a potential therapeutic target..